Can the use of specific isomers improve the safety and efficacy of nonsteroidal antiinflammatory drugs?

Does Ramadan Fasting Increase duodenal ulcer perforation?

Introduction: In Ramadan, healthy adult Muslims are obliged to fast. Prolonged fasting increase gastric acid and pepsin levels, which promote the risk of duodenal ulcer perforation (DUP). Effects of Ramadan fasting on DUP have not been thoroughly studied yet, and the limited number of studies investigating the impact of Ramadan fasting on DUP yielded discrepant results. This study aimed to eval...

Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.

STUDY OBJECTIVE We investigate the efficacy and safety of oral paracetamol compared with oral nonsteroidal antiinflammatory drugs or combination therapy in relieving pain after blunt limb injury in an emergency department (ED). METHODS This was a double-blind, randomized, controlled study in an ED of a university hospital in the New Territories of Hong Kong. Three hundred adult patients with ...

A Rare Complication with the Concomitant use of Warfarin and Nonsteroidal Anti-Inflammatory Drugs: Hemoperitoneum and Intramural Small Bowel Hematoma

Herbal medicine in Egypt

Traditional medicine has been used since the dawn of history for treating human illness. Herbal medicine constituted the main type of traditional medicine. This type of treatment prevailed during different times of history in different countries, may be until the beginning of the 19th century. By that time a scientific revolution, in nearly all fields started. Much progress was made in the fiel...

Synthesis and Pharmacological Evaluation of Antiinflammatory Mutual Amide Prodrugs

Nonsteroidal antiinflammatory drugs have been widely used for the management of inflammation, pain and nociception. Gastric intolerance caused by most of the nonsteroidal antiinflammatory drugs used today restricts their use. Several approaches have been proposed to modify the parent nonsteroidal antiinflammatory drugs molecule in order to reduce their gastric toxicity. Oral prodrug approach is...